Colchicine inhibits elevations in both alveolar-capillary membrane permeability and lavage surfactant after exposure of the rat to phosgene.
Inhal Toxicol 1992 Oct; 4(4):383-392
The effects of colchicine on phosgene (75445) induced changes in alveolar/capillary membrane permeability were studied in rats. Male Sprague-Dawley-rats were injected intraperitoneally with 0 or 10mg/kg colchicine 30 minutes before being exposed to 0.5 part per million phosgene or filtered air for 60 minutes. Selected rats were killed 0 to 1 or 24 to 25 hours after phosgene administration, and received an intravenous injection of iodine-125 (I-125) tagged bovine serum albumin shortly before death. Lung lavage fluid was used for neutrophil counts and protein concentration determinations. Changes in alveolar/capillary membrane permeability were determined from the amounts of I-125 activity recovered in the lavagate. Effects on pulmonary surfactant secretion were assessed through changes in phospholipid content of the lavagate. Phosgene alone caused significant increases in lavage fluid neutrophil counts and protein concentrations 24 to 25 hours after exposure. Phosgene also caused significant increases in alveolar/capillary membrane permeability immediately after exposure and significant increases in pulmonary surfactant secretion 24 to 26 hours postexposure. Colchicine inhibited both these effects. The authors conclude that colchicine may have a potential role in lung injury that is associated with increased permeability or extracellular surfactant.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Drugs; Toxic-gases; Organo-chlorine-compounds; In-vivo-studies; Laboratory-animals; Lung-tissue; Membrane-dysfunction; Phospholipids; Prophylaxis; Leukocytes
Medicine University of Tennessee Room H-314, Coleman Bldg Memphis, TN 38163
University of Tenn Center Health Scien, Memphis, Tennessee