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Pulmonary reactivity to vanadium pentoxide following subchronic inhalation exposure in a non-human primate animal model.

Authors
Knecht-EA; Moorman-WJ; Clark-JC; Hull-RD; Biagini-RE; Lynch-DW; Boyle-TJ; Simon-SD
Source
J Appl Toxicol 1992 Dec; 12(6):427-434
NIOSHTIC No.
00211573
Abstract
The changes in pulmonary reactivity resulting from repeated vanadium- pentoxide (1314621) (V2O5) exposure were evaluated in monkeys. Adult, male cynomolgus-monkeys were exposed by inhalation for 6 hours/day, 5 days/week for 26 weeks to 0.1 to 1.1 milligram V2O5/cubic meter (mg/m3). One group was exposed to 0.1mg/m3 Monday, Wednesday, and Friday, and 1.1mg/m3 on Tuesday and Thursday. Another group was exposed to 0.5mg/m3, 5 days/week. Before exposure, challenge with V2O5 caused an impairment in pulmonary function. The airway obstruction was accompanied by a significant influx of inflammatory cells into the lung. Subchronic V2O5 inhalation did not produce an increase in V2O5 reactivity in comparison to the control group, and cytological, immunological and skin test results indicated the absence of allergic sensitization. A trend toward decreased pulmonary reactivity was found following subchronic V2O5 inhalation. Pulmonary reactivity to V2O5 was affected, as well as nonspecific reactivity to methacholine. The authors suggest that the absence of increased pulmonary reactivity to V2O5 following subchronic inhalation may be related to the induction of tolerance under the exposure conditions used in the study.
Keywords
NIOSH-Author; Inhalation-studies; Laboratory-animals; Inhalants; Toxic-gases; Organic-vapors; Vanadium-compounds; Respiratory-system-disorders
CODEN
JJATDK
CAS No.
1314-62-1
Publication Date
19921201
Document Type
Journal Article
Fiscal Year
1993
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0260-437X
NIOSH Division
DBBS
Priority Area
Respiratory-system-disorders
Source Name
Journal of Applied Toxicology
State
OH
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