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Occupational Risks of Pesticide Exposure for Females.

Authors
Swartz-WJ
Source
NIOSH 1992 Sep :1-27
Link
NIOSHTIC No.
00210903
Abstract
The effects of exposure to methoxychlor (72435) (MXC) on reproductive functions in nonpregnant and pregnant mice were studied. Sexually mature virgin female CD-I-mice were exposed to 1.25, 2.5, or 5.0 milligrams (mg) MXC via oral gavage for 5 consecutive days each week for either 2 or 4 weeks. A dose dependency of MXC was noted in inducing persistent vaginal estrus. Ovaries of MXC and estradiol-17beta (E-17beta) exposed mice weighed significantly less than controls. There was also an increase in the number of atretic large follicles in the E-17beta group and in those mice treated with the two highest doses of MXC, indicating a potential reduction in the immediate fertility of the mice. Increased lipid accumulation was noted in interstitial cells and theca cells of both E-17beta treated and 5.0mg MxC treated mice. This chemical appears to closely mimic the effects on the female ovary induced by estrogen and raises concern whether such an exposure of an adult female will interfere with the normal hormonal environment and thus jeopardize future pregnancy. These alterations appear to be reversible once exposure stops. Pregnant mice were exposed to 2.5, 5.0, or 7.5mg of MXC by gavage from day six to 15 of gestation. Mice exposed to 7.5mg MXC were not able to carry their litters to term. Results revealed a significant increase in the length of gestation of mice exposed to both E-17 beta and 5.0mg MXC. Females from a subsequent unexposed litter displayed a significant advance in time of vaginal opening, a residual effect of MXC from a mother exposed during a previous pregnancy.
Keywords
NIOSH-Grant; Reproductive-system-disorders; Reproductive-effects; Reproductive-hazards; Laboratory-animals; Insecticides; Toxic-effects; Prenatal-exposure
Contact
Louisiana State University, School of Medicine, Department of Anatomy, 1901 Perdido Street, New Orleans, LA 70112
CAS No.
72-43-5
Publication Date
19920902
Document Type
Final Grant Report
Funding Amount
706204.00
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
PB93-137040
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00835
NIOSH Division
OEP
Source Name
National Institute for Occupational Safety and Health
State
LA
Performing Organization
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
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