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Occupational exposures and birth defects.

Authors
Mitchell-AA; Louik-C
Source
Slone Epidemiology Unit, Boston University School of Medicine, Brookline, Massachusetts 1992 May; :1-48
Link
NIOSHTIC No.
00210242
Abstract
The utility of the job exposure matrix (JEM) of NIOSH in occupational teratogen research was assessed. Information was taken from the Slone Epidemiology Unit Birth Defects Study (BDS). The JEM was used to assign specific workplace exposures to the mothers and fathers of the 11,000 malformed infants in the BDS data file. BDS job title/industry codes were translated into codes compatible with the JEM. Computer software was developed to produce tabulations which provided frequencies of each listed exposure in each birth defect category as well as comparisons to the remaining categories of defects. A detailed exploration of certain aspects of the data was conducted involving the testing of a specific hypothesis. Neither the absolute attribution of exposure nor the assessment of exposure probability by the JEM provided a credible measure of exposure. The authors conclude that the NIOSH JEM cannot be usefully applied to the BDS data base to assess risks of occupational exposures in relation to birth defects.
Keywords
NIOSH-Grant; Reproductive-system-disorders; Reproductive-hazards; Risk-analysis; Epidemiology; Occupational-exposure
Contact
Slone Epidemiology Unit Boston Univ Med/drug Epid Unit 1371 Beacon Street Brookline, MA 02146
Publication Date
19920528
Document Type
Final Grant Report
Funding Amount
518231
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
PB93-118628
NTIS Price
A04
Identifying No.
Grant-Number-R01-OH-02598
NIOSH Division
OEP
Priority Area
Reproductive-system-disorders
Source Name
Slone Epidemiology Unit, Boston University School of Medicine, Brookline, Massachusetts
State
MA
Performing Organization
Boston University, Boston, Massachusetts
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