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Synergistic interaction of nitrogen dioxide and ozone on rat lungs: acute responses.

Authors
Gelzleichter-TR; Witschi-H; Last-JA
Source
Toxicol Appl Pharmacol 1992 Sep; 116(1):1-9
NIOSHTIC No.
00210122
Abstract
The synergistic interaction between nitrogen-dioxide (10102440) and ozone (10028156) was investigated in Sprague-Dawley-rats. Rats were exposed for 6 hours per day for 3 days to ozone (0.2 to 0.8 parts per million (ppm)), nitrogen-dioxide (3.6 to 14.4ppm), or combinations of both oxidant air pollutants. Responses were quantified by changes in total protein content of lung lavage supernatants or by alterations in the content of specific cell types in lavage pellets. Results revealed a concentration dependent synergistic response upon combined exposure. Concurrent exposure was necessary to elicit positive interaction which is a greater than additive response. No positive interactions were seen when rats were exposed sequentially to ozone or nitrogen-dioxide. Given the apparent disappearance rates of ozone during combined exposure, predicted outcomes were modeled on the assumption that ozone and nitrogen-dioxide were reacting in the chambers to form nitrogen-pentoxide. The authors conclude that synergistic toxicologic interactions between ozone and nitrogen-dioxide are found only at concentrations much higher than would be found in environmental or occupational settings. The potential for chronic toxicological responses with levels below those causing acute responses requires further investigation.
Keywords
Laboratory-animals; Nitrogen-oxides; Lung-cells; Protein-chemistry; Synergism; Environmental-pollution; Combustion-gases; Toxic-gases
CODEN
TXAPA9
CAS No.
10102440; 10028156
Publication Date
19920901
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
1
ISSN
0041-008X
Source Name
Toxicology and Applied Pharmacology
State
CA
Performing Organization
University of California - Davis
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