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Use of urinary formic acid as a biologic exposure index of methanol exposure.

Authors
Franzblau-A; Levine-SP; Schreck-RM; D'Arcy-JB; Qu-Q
Source
Appl Occup Environ Hyg 1992 Jul; 7(7):467-471
NIOSHTIC No.
00209555
Abstract
The use of urinary formic-acid as a biologic exposure index of occupational exposure to methanol (67561) was tested. Methanol vapor delivered to the Rochester type exposure chamber was maintained at 192 to 204 parts per million. Four human subjects participated. Urine specimens collected immediately before and after a 6 hour exposure were analyzed for formic-acid. Correction factors for the presence of creatinine and for specific gravity were introduced. However, regardless of the method of correction, mean formic-acid level in urine increased slightly immediately after exposure, and returned to baseline values by 16 hours after the end of exposure in all four subjects. Spiked samples showed a 90.4% recovery of formic-acid. The authors conclude that the current biologic exposure index for methanol using urinary formic-acid measurement 16 hours after exposure may not be as valid as thought. Differences between their results and the only other published study may be due to critical differences in study design.
Keywords
NIOSH-Publication; NIOSH-Grant; Alcohols; Biochemical-analysis; Biological-monitoring; Urinalysis; Inhalation-studies; Metabolism; Occupational-exposure; Toxic-vapors
Contact
Environmental & Indust Health University of Michigan 1420 Washington Heights Ann Arbor, MI 48109-2029
CODEN
AOEHE9
CAS No.
67-56-1
Publication Date
19920701
Document Type
Journal Article
Funding Amount
1353157.00
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02666; Grant-Number-R01-OH-03024
Issue of Publication
7
ISSN
1047-322X
Priority Area
Grants-other
Source Name
Applied Occupational and Environmental Hygiene
State
MI
Performing Organization
University of Michigan at Ann Arbor, Ann Arbor, Michigan
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