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Reproductive toxicity of ethylene glycol monomethyl ether, ethylene glycol monoethyl ether and their acetates.

Authors
Wess-JA
Source
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):43-45
NIOSHTIC No.
00209509
Abstract
Studies on animals concerning the reproductive and developmental hazards of ethylene-glycol-monomethyl-ether (109864) (EGME), ethylene-glycol-monoethyl-ether (110805) (EGEE), ethylene-glycol- monomethyl-ether-acetate (110496) (EGMEA), and ethylene-glycol- monoethyl-ether-acetate (111159) (EGEEA) were reviewed and discussed. Limited evidence suggested that EGME, EGEE or their acetates cause adverse effects on the male reproductive system in humans. Treating pregnant females of various animal species with EGME, EGEE, or EGEEA has resulted in decreased body weight and body weight gain, prolonged gestation and a significantly increased mean number and percentage of resorptions and infertility. After reviewing the evidence concerning EGME and EGEE, NIOSH recommended that exposure to these glycol ethers be minimized in the workplace. OSHA announced in 1987 a notice of intended change for EGME, EGEE and their acetates and the agency was engaged in rule making for these chemicals. NIOSH recommendations included exposure limits of average, 0.5ppm EGEE or EGEEA as a time weighted average, and prohibiting dermal contact with all four compounds.
Keywords
NIOSH-Author; Toxic-effects; Reproductive-system-disorders; Glycols; Laboratory-animals; Standards; Reproductive-hazards
CODEN
SWEHDO
CAS No.
109-86-4; 110-80-5; 110-49-6; 111-15-9
Publication Date
19920601
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
ISSN
0355-3140
Priority Area
Reproductive-system-disorders
Source Name
Scandinavian Journal of Work, Environment and Health
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