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Effects of parental occupational exposure to solvents and lead on spontaneous abortion.

Authors
Lindbohm-L; Taskinen-H; Kyyronen-P; Sallmen-M; Anttila-A; Hemminki-K
Source
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):37-39
NIOSHTIC No.
00209507
Abstract
Finnish studies on the possible relationship of parental occupational exposure to organic solvents or inorganic lead (7439921) to the incidence of spontaneous abortion were reviewed. Four groups of persons were studied: pharmaceutical factory workers, laundry and dry cleaning workers, and men and women biologically monitored for solvent exposure. The pregnancies of the workers or the wives of the male workers were identified from the nationwide database on births and spontaneous abortions treated in hospitals in Finland between 1973 and 1983. The odds ratio of spontaneous abortion for maternal exposure to solvents was increased among the pharmaceutical factory workers and significantly increased among the women monitored for solvents. For the individual solvents, high exposures to methylene-chloride (75092), tetrachloroethylene (127184), and aliphatic hydrocarbons were associated with spontaneous abortion. The odds ratio for toluene (108883) was elevated in a small group of shoe workers. Maternal exposure to lead was not associated with increased incidence of spontaneous abortion. Paternal exposure to organic solvents in general and high exposure to toluene and miscellaneous solvents such as thinners showed increased risk for spontaneous abortion.
Keywords
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Solvent-vapors; Reproductive-hazards; Pharmaceutical-industry; Dry-cleaning-solvents; Dry-cleaning-industry; Occupational-exposure; Heavy-metals
CODEN
SWEHDO
CAS No.
7439-92-1; 75-09-2; 127-18-4; 108-88-3
Publication Date
19920601
Document Type
Journal Article
Funding Amount
194924
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-01910
ISSN
0355-3140
Priority Area
Reproductive-system-disorders
Source Name
Scandinavian Journal of Work, Environment and Health
Performing Organization
Institute of Occupational Health, Helsinki, Finland
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