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Biological monitoring for occupational exposures to ortho-toluidine and aniline.

Authors
Stettler-LE; Savage-RE; Brown-KK; Cheever-KL; Weigel-WW; DeBord-DG; Teass-AW; Dankovic-D; Ward-EM
Source
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):78-81
NIOSHTIC No.
00209451
Abstract
Biological monitoring methods developed for a NIOSH study of worker exposures to o-toluidine (95534) and aniline (62533) at a facility producing an antioxidant and an accelerator used in tire manufacturing were described. An excess of bladder cancers had been determined among workers at this facility which had been attributed to o-toluidine and aniline exposures. All of the methods developed to measure aniline and o-toluidine in the urine and human albumin relied on the measurement of free amines following base hydrolysis to convert acetylated metabolites in the urine or adducts back to the parent compounds. An analysis of worker urine clearly showed that the uptake of both aniline and o-toluidine occurred in the workplace. The data for o-toluidine were the most striking and indicated that exposed workers were absorbing o-toluidine during the workshift, as the average concentration in the postshift samples compared with the preshift samples was six fold higher.
Keywords
NIOSH-Author; Urinalysis; Blood-analysis; Carcinogens; Analytical-methods; Chemical-industry-workers; Chemical-analysis; Biological-monitoring; Anilines
CODEN
SWEHDO
CAS No.
95-53-4; 62-53-3
Publication Date
19920601
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
ISSN
0355-3140
Source Name
Scandinavian Journal of Work, Environment and Health
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