Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Interleukin 1 and its inhibition in an inflammatory reaction caused by Aspergillus umbrosus.

Authors
Manninen-A; Lewis-DM; Olenchock-SA; Sorenson-WG; Mull-JC; Whitmer-M; Terho-EO; Husman-KR; Kotimaa-M
Source
Scand J Work, Environ & Health 1992 Jun; 18(Suppl 2):75-77
NIOSHTIC No.
00209450
Abstract
Male Sprague-Dawley-rats were exposed to an antigen extract and antigen plus endotoxin in a study of the inhibition of interleukin-1 (IL-1) in an inflammatory reaction resulting from exposure to Aspergillus-umbrosus. Rats were exposed three times, 3 days apart to antigen extract at 100 microliter/100 grams body weight and endotoxin at 1 million endotoxin units/milliliter, or to antigen extract alone. Alveolar macrophages were obtained through lavage. Exposure to A-umbrosus increased IL-1 activity 12 times in alveolar macrophages in-vivo. Total cell counts showed that the exposure caused an inflammatory condition in the lungs because the number of macrophages in the lavage fluids of the exposed rats increased from could increase IL-1 activity more than exposure to A-umbrosus plus endotoxin. The authors conclude that A-umbrosus can cause an IL-1- mediated inflammatory reaction similar to endotoxin. A-umbrosus is one of the causative agents of hypersensitivity pneumonitis. The authors suggest that IL-1 may also be involved in the pathogenesis of hypersensitivity pneumonitis.
Keywords
NIOSH-Author; Laboratory-animals; Lung-cells; Alveolar-cells; Bacterial-dusts; Toxins; Fungi; In-vivo-studies; Respiratory-system-disorders; Respiratory-hypersensitivity
CODEN
SWEHDO
Publication Date
19920601
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
ISSN
0355-3140
Priority Area
Respiratory-system-disorders
Source Name
Scandinavian Journal of Work, Environment and Health
TOP