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HHE Report No. HETA-90-140-2221, George Washington University Medical Center, Washington, D.C.

Authors
Seitz-TA; Deitchman-S
Source
NIOSH 1992 May:17 pages
NIOSHTIC No.
00209043
Abstract
Exposure during aerosolized pentamidine administration was investigated in response to concerns raised by a published report about pulmonary diffusing capacity in a health care worker and diagnosis of idiopathic pulmonary fibrosis in a worker administering pentamidine (100334) at the George Washington University Medical Center (SIC-8069) in Washington, DC. Pentamidine has been used in the treatment of protozoal diseases, particularly Pneumocystis- carinii pneumonia, an opportunistic infection in patients with compromised immune function. Environmental measurements indicated a pentamidine concentration of 0.04 micrograms/cubic meter in a personal breathing zone air sample for a nurse involved in administering the medication, and 0.09 and 0.13 micrograms/cubic meter in area air samples outside the treatment room. Of four employees interviewed, two expressed occasional symptoms of mild chest tightness associated with exposure to the medication. The authors conclude that the recognized irritant effects of pentamidine, its potential to cause bronchospasm, and the risk of tuberculosis transmission in these settings justify continued efforts to minimize worker exposure.
Keywords
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; NIOSH-Technical-Assistance-Report; HETA-90-140-2221; Hazard-Confirmed; Region-3; Health-care-personnel; Pharmaceuticals; Medical-treatment; Occupational-exposure;
CAS No.
100-33-4;
Publication Date
19920501
Document Type
Hazard Evaluation and Technical Assistance;
Fiscal Year
1992
NTIS Accession No.
PB92-231034
NTIS Price
A03
Identifying No.
HETA-90-140-2221
NIOSH Division
DSHEFS;
SIC Code
8069;
Source Name
Hazard Evaluations and Technical Assistance Branch, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, Report No. HETA-90-140-2221, 17 pages, 35 references
State
WA; OH;
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