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Prophylactic Chelation Therapy: A Review of the Literature.

Authors
Bridbord-K
Source
NIOSH 1976 Mar:25 pages
Link
NIOSHTIC No.
00208296
Abstract
This report presented a review of the literature concerning the usefulness of prophylactic chelation therapy as a means of controlling occupational lead (7439921) intoxication. Reports concerning both the routine use of chelation therapy to avoid high blood lead concentrations and the use of chelation therapy to lower already elevated blood lead levels were reviewed. Studies included the use of calcium-disodium-ethylenediamine-tetraacetic-acetate (EDTA) and penicillamine therapies. The general consensus of opinion among those treating this occurrence in the field was that chelation or similarly acting agents have a definite place in the treatment regimen. The prophylactic use of these agents, however, has been viewed as being somewhat harmful to the health of the individual being so treated in that it can cause kidney damage, symptomatic lead poisoning, increased absorption of lead from the gastrointestinal tract, and disruption in the metabolism of trace metals other than lead. The author concludes that no support can be given to the routine prophylactic use of chelating agents to avoid high lead levels in exposed workers.
Keywords
NIOSH-Author; Medical-treatment; Lead-poisoning; Heavy-metal-poisoning; Blood-analysis; Preventive-medicine; Chelates; Lead-compounds; Chelating-agents;
CAS No.
7439-92-1;
Publication Date
19760316
Document Type
Other;
Fiscal Year
1976
NTIS Accession No.
PB92-221423
NTIS Price
A03
Source Name
NIOSH, Rockville, Maryland, 25 pages, 26 references
State
MD;
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