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Monohaloacetic Acids.

Authors
Anonymous
Source
Franklin Research Center, Silver Spring, Maryland 1980 Dec:99 pages
Link
NIOSHTIC No.
00207677
Abstract
The monohaloacetic acids were reviewed, including information on occupational exposure, physical properties, toxicity, and structure/activity relationships. A detailed review and analysis was conducted of the biological effects of chloroacetic-acid (79118), sodium-chloroacetate (3926623), fluoroacetic-acid (144490), sodium-fluoroacetate (62748), iodoacetic-acid (64697), sodium- iodoacetate (305533), and bromoacetic-acid (79083). Topics included: human effects; epidemiologic studies; animal toxicity; diagnosis; antidotes; absorption, distribution, metabolism, and excretion; biochemistry; mutagenicity; carcinogenicity; and teratogenicity. Accurate information on the number of workers potentially exposed to these compounds was not available. Sodium- fluoroacetate has been widely used as a mammalian pest control agent. Although these compounds have different modes of action, all of them inhibit various metabolic pathways. Based on the acute toxicity to rats, fluoroacetate was the most toxic.
Keywords
NIOSH-Contract; Contract-210-79-0091; Pesticides; Epidemiology; Occupational-exposure; Halogenated-hydrocarbons; Toxic-effects; Pest-control; Comparative-toxicology;
CAS No.
79-11-8; 3926-62-3; 144-49-0; 62-74-8; 64-69-7; 305-53-3; 79-08-3;
Publication Date
19801205
Document Type
Final Contract Report;
Funding Type
Contract;
Fiscal Year
1981
NTIS Accession No.
PB92-206077
NTIS Price
A06
Identifying No.
Contract-210-79-0091
Source Name
Franklin Research Center, Silver Spring, Maryland
State
MD;
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