Evaluation of the peripheral nervous system among workers employed in the production of chemicals contaminated with 2,3,7,8- Tetrachlorodibenzo-p-dioxin.
Sweeney-MH; Fingerhut-MA; Connally-LB; Hornung-R
NIOSH 1990 Jul; :1-311
The long term effects on the peripheral nervous system in workers with past exposure to production products contaminated with 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD) were evaluated. The severity of the current neurologic status was compared to the levels of TCDD measured in the serum of study subjects. Workers who were employed at two chemical factories at which chemicals contaminated with TCDD were manufactured, and a group of unexposed referents were assessed in a cross sectional medical study in 1987 through 1988. Questionnaires were used to collect follow up data. There were 281 workers and 260 referents who were interviewed and medically examined. Peripheral neuropathy was found in about 18% of workers and 19% of referents. Serum TCDD levels ranged from 2 to 3390 parts per trillion (ppt) for 272 workers and from 2 to 20ppt for 86 referents tested. No dose response relationship was observed between TCDD levels present at the time of the examination and the occurrence of peripheral neuropathy in this previously exposed population. The authors conclude that exposure to TCDD caused no excess chronic peripheral neuropathy in a group of exposed workers compared to unexposed referents.
NIOSH-Author; Toxic-effects; Neurotoxic-effects; Environmental-pollution; Herbicides; Agricultural-chemicals; Chemical-industry-workers; Epidemiology; Occupational-exposure
NTIS Accession No.
Neurotoxic Disorders; Neurotoxic-effects
Industrywide Study Branch, Division of Surveillance, Hazard Evaluations and Field Studies, NIOSH, 311 pages, 315 references