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Rank Analysis of Urine Data to Identify Differentially Exposed Subcohorts for a Uranium Enrichment Mortality Study.

Authors
Bloom-TF; Brown-DP
Source
NIOSH 1988 May:27 pages
Link
NIOSHTIC No.
00207662
Abstract
As part of a cohort mortality study at a uranium enrichment facility, investigators used urinalysis data collected by the facility to identify three department based subcohorts exposed to uranyl-fluoride (7783815). Each subcohort was considered to represent employees at greater exposure risk. Details are presented concerning the development and application of the methods of subcohort identification. Inhalation of uranyl-fluoride was the primary exposure of concern at this facility. For the first subcohort selection method all workers who were ever employed in departments in which at least 100 urine uranium (7440611) analyses had been reported over the 28 year span of the data base were included. An additional method was used which allowed two additional subcohorts to be taken from the first cohort. The method was based on the assumption that a department having a greater percentage of measurements exceeding action level criteria had a greater exposure potential. The usefulness of these methods for identifying differentially expose subcohorts using urinalysis data was explored. These methods of subcohort identification were intended to supplement exposure characterization methods employed in epidemiologic studies based on duration of employment and job description. Advantages and disadvantages of the methods were discussed.
Keywords
NIOSH-Author; Field-Study; IWS-121-10B; Mortality-surveys; Epidemiology; Urinalysis; Biological-monitoring; Radiation-exposure; Occupational-exposure; Uranium-compounds;
CAS No.
7783-81-5; 7440-61-1;
Publication Date
19880501
Document Type
Industry Wide;
Fiscal Year
1988
NTIS Accession No.
PB92-205939
NTIS Price
A03
Identifying No.
IWS-121-10B
Source Name
NIOSH, Cincinnati, Ohio, Report No. IWS-121-10B, 27 pages, 8 references
State
OH;
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