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The clinical relevance of asbestos-induced pleural fibrosis.

Authors
Schwartz-DA
Source
Ann NY Acad Sci 1991 Dec; 643:169-177
NIOSHTIC No.
00207136
Abstract
The association between asbestos (1332214) induced pleural fibrosis and parenchymal changes was investigated in 1211 asbestos exposed sheet metal workers. Of those having pleural fibrosis, circumscribed plaques were seen in 260 and diffuse pleural thickening was seen in 74. Pulmonary function testing, high resolution computed tomographic (HRCT) scans of the lung parenchyma, and bronchoalveolar lavage were performed. The presence of circumscribed plaques was related to significant decrements in forced vital capacity (FVC) and one second forced expiratory volume. Workers with diffuse pleural thickening had significant decrements in FVC, total lung capacity (TLC), and carbon-monoxide diffusion capacity (DLco) after controlling for age, years in the trade, and pack years of smoking. This group also exhibited an increased percentage of lymphocytes in their lavage fluid and parenchymal abnormalities on their HRCT scans. Workers with circumscribed plaques also had elevated lavage fluid lymphocyte populations and HRCT parenchymal abnormalities. Circumscribed plaques and diffuse pleural thickening were responsible for a 14% decrease in FVC, a 13% decrease in TLC, and an 11% decrease in DLco.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Asbestos-dust; Occupational-exposure; Metal-workers; Chest-X-rays; X-ray-analysis; Lung-fibrosis; Pulmonary-function-tests
Contact
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
CODEN
ANYAA9
CAS No.
1332-21-4
Publication Date
19911231
Document Type
Journal Article
Funding Amount
122514
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000093
ISSN
0077-8923
Priority Area
Pulmonary System Disorders
Source Name
Annals of the New York Academy of Sciences
State
IA
Performing Organization
University of Iowa, Iowa City, Iowa
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