Behavioral toxicology of volatile organic solvents V. Comparisons of the behavioral and neuroendocrine effects among n-alkanes.
J Amer Coll Toxicol 1991 Dec; 10(6):639-646
Adult male CD-1-mice were exposed to octane (111659), heptane (142825), hexane (110543), or pentane (109660) in an inhalation chamber to determine the effect on task performance and stimulation of hypothalamic pituitary activity. Concentration data ranged from 100 to 100,000 parts per million (ppm) in the task tests and from 100 to 10,000ppm in evaluations of adrenocorticotropin hormone (ACTH) levels. In octane exposed animals, response behavior was diminished at concentrations greater than 1000ppm with almost complete nonresponse seen at at 5600ppm. At 10,000ppm the mice participated in circular locomotive activity. Heptane increased the response rates at levels of 1000 to 3000ppm, but nearly abolished response at 5600ppm. No effect was observed at hexane concentrations of less than 3000ppm, but response was less than 50% at 5600ppm and abolished at 17,000ppm. A slightly increased response was noted in animals exposed to 10,000ppm pentane, but exposure to 30,000ppm decreased responses by about 50%. For each of the agents studied ACTH levels increased in a dose dependent manner, particularly between 3000 to 10,000ppm. Pentane produced the smallest changes up to 3000ppm and octane produced the largest increase at 10,000ppm. The authors conclude that a direct relationship exists between aliphatic carbon chain length and the ability of n-alkanes to alter performance.
NIOSH-Publication; NIOSH-Grant; Grants-other; Inhalation-studies; Laboratory-animals; Hormone-activity; Neuromotor-system-disorders; Organic-solvents; Solvent-vapors; Alkanes
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Journal of the American College of Toxicology
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