Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Serum growth factors and oncoproteins in firefighters.

Authors
Ford-J; Smith-S; Luo-C; Friedman-Jimenez-G; Brandt-Rauf-P; Markowitz-S; Garibaldi-K; Niman-H
Source
Occup Med 1992 Feb; 42(1):39-42
NIOSHTIC No.
00206744
Abstract
A study of serum growth factors and oncoproteins in firefighters was conducted to determine if serum growth factors or oncoproteins could serve as biomarkers for the development of cancer or nonmalignant respiratory disease. The cohort of 33 New York City firefighters, mean age 55 years, was selected from among participants in a medical surveillance program. The comparisons consisted of 16 healthy medical center volunteers, mean age 54 years. Blood samples were collected and assayed for beta transforming growth factor (bTGF), platelet derived growth factor (PDGF), and the oncogene proteins ras, fes, myc, myb, mos, src, and int using an immunoblotting technique. Medical and occupational histories of the subjects were reviewed. No positive bands for PDGF, ras, fes, myc, myb, mos, src, or int were found in any of the serum samples. Fourteen firefighters were positive for bTGF, but none of the comparisons were. The bTGF positive and negative firefighters were similar with regard to age and years of employment in firefighting. Compared to the seronegative firefighters, bTGF positive firefighters were slightly more likely to have abnormal chest X-rays, a prior history of asbestos (1332214) exposure, fewer pulmonary complaints, and to be nonsmokers. None of the differences were statistically significant. The authors conclude that bGTF may be related to pathological processes induced by firefighting exposure. It may be suitable for monitoring pathological changes related to nonmalignant respiratory disease or cancer in firefighters and other exposed populations.
Keywords
NIOSH-Publication; NIOSH-Grant; Cancer; Firemen; Epidemiology; Blood-serum; Growth-factors; Biochemical-indicators; Malignant-neoplasms; Cigarette-smoking; Occupational-medicine; Occupational-exposure
Contact
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
CODEN
OCMEE8
CAS No.
1332-21-4
Publication Date
19920201
Document Type
Journal Article
Funding Amount
102342
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00076
Issue of Publication
1
ISSN
0962-7480
Source Name
Occupational Medicine
State
NY
Performing Organization
Columbia University New York, New York, New York
TOP