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Airway injury in swine confinement workers.

Authors
Schwartz-DA; Landas-SK; Lassise-DL; Burmeister-LF; Hunninghake-GW; Merchant-JA
Source
Ann Intern Med 1992 Apr; 116(8):630-635
NIOSHTIC No.
00206630
Abstract
Lung disease among workers in swine confinement buildings was studied to determine if respiratory alterations are attributable to airway or interstitial injury. Participants were selected from a cohort of 207 swine confinement workers (SCWs); referents were blue collar workers whose farming work ended 5 years before the study. Testing included chest radiographs, spirometric evaluation, and assessment of lung volumes and diffusing capacities. A methacholine challenge was performed and a 10% decrease in forced expiratory volume was calculated. Endobronchial (EB) biopsy and bronchoalveolar lavage (BAL) were performed on all study subjects and inflammatory cells were counted. With respect to the referents, SCWs exhibited more work related symptoms and chronic respiratory complaints and also exhibited enhanced airway response to methacholine. BAL cellularity was similar in all groups and there was no evidence of alveolitis among SCWs. EB differences were restricted to thickening of the bronchial basement membranes in the SCW. The authors conclude that symptomatic SCWs are at risk for airway but not parenchymal lung injury.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Respiratory-system-disorders; Animal-husbandry-workers; Epidemiology; Lung-disorders; Occupational-exposure; Occupational-respiratory-disease
Contact
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
CODEN
AIMEAS
Publication Date
19920415
Document Type
Journal Article
Funding Amount
122514
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000093
Issue of Publication
8
Priority Area
Pulmonary System Disorders
Source Name
Annals of Internal Medicine
State
IA
Performing Organization
University of Iowa, Iowa City, Iowa
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