Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Serum oncoproteins and growth factors in asbestosis and silicosis patients.

Authors
Brandt-Rauf-PW; Smith-S; Hemminki-K; Koskinen-H; Vainio-H; Niman-H; Ford-J
Source
Int J Cancer 1992 Apr; 50(6):881-885
NIOSHTIC No.
00206621
Abstract
Serum levels of oncoproteins and growth factors in asbestosis and silicosis patients were examined. The study cohort consisted of 46 patients (36 asbestosis and ten silicosis) who supplied serum samples between March 1983 and August 1987. Followup study through June 1991 showed that 15 from the asbestosis group and three from the silicosis group developed cancer. Blood samples were analyzed for increased levels of the oncoproteins ras, myc, myb, fes, src, int-1, and mos, as well as for transforming growth factor-beta-1 and platelet-derived-growth-factor-B (PDGF); analysis involved monoclonal antibodies against marker peptide sequences and serial dilution with densitometry. Fifty of the 91 samples were positive for at least one of the oncoproteins or growth factors. Elevated oncoproteins were found only in the asbestosis patients, while elevated PDGF occurred in both asbestosis and silicosis patients. Only the ras oncogene (p21) protein was significantly elevated. The relationship between elevated PDGF levels and advanced pneumoconiosis was also significant. There was a greater tendency for patients with progressive pneumoconiosis to be PDGF positive. The authors conclude that elevated serum p21 may be a useful marker for early diagnosis of pulmonary cancer and that elevated PDGF may serve as a marker of progressive and advanced pneumoconiosis.
Keywords
NIOSH-Publication; NIOSH-Grant; Cancer; Growth-factors; Blood-analysis; Immunological-tests; Epidemiology; Carcinogenesis; Lung-cancer; Respiratory-system-disorders
Contact
Environmental Sciences Columbia University Sch of PH 60 Haven Avenue/b-1 Level New York, NY 10032
CODEN
IJCNAW
Publication Date
19920401
Document Type
Journal Article
Funding Amount
102342
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00076
Issue of Publication
6
ISSN
0020-7136
Priority Area
Respiratory-system-disorders
Source Name
International Journal of Cancer
State
NY
Performing Organization
Columbia University New York, New York, New York
TOP