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A Dose-Response Analysis and Quantitative Assessment of Lung Cancer Risk and Occupational Cadmium Exposure.

Authors
Stayner-L; Smith-R; Thun-M; Schnorr-T; Lemen-R
Source
NIOSH 1990 Sep:35 pages
Link
NIOSHTIC No.
00206158
Abstract
A quantitative assessment was performed of the risk of lung cancer from exposure to cadmium (7440439) in a population of workers at a facility that processed cadmium metals and compounds. The population consisted of all workers who worked in a production area for at least 6 months from 1940 through 1969; the vital status of the workers was updated through 1984. A total of 606 white male workers, contributing 16,898 person years and 162 deaths were analyzed. A statistically significant dose response was evident in nearly all of the Poisson regression models evaluated. A nearly significant excess in mortality from lung cancer was noted for the entire cohort. Mortality from lung cancer was significantly elevated among nonHispanic workers, workers in the highest cadmium exposure group, and among workers with 20 or more years since first exposure. Based on these analyses, the lifetime excess lung cancer risk at the current OSHA standard for cadmium fumes of 100 micrograms per cubic meter was estimated to be approximately 50 to 111 lung cancer deaths per 1000 workers exposed to cadmium for 45 years. The authors conclude that efforts should be made to further reduce the risk by lowering occupational exposures to cadmium to the lowest level feasible.
Keywords
NIOSH-Author; Cadmium-compounds; Risk-analysis; Epidemiology; Cancer-rates; Carcinogens; Lung-cancer; Respiratory-system-disorders; Occupational-exposure;
CAS No.
7440-43-9;
Publication Date
19900904
Document Type
Other;
Fiscal Year
1990
NTIS Accession No.
PB92-184282
NTIS Price
A04
NIOSH Division
DSDTT;
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Source Name
Division of Standards Development and Technology Transfer, NIOSH, Cincinnati, Ohio, 35 pages, 34 references
State
OH;
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