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The role of superoxide radical in chromium(VI)-generated hydroxyl radical: the Cr(VI) Haber-Weiss cycle.

Authors
Shi-X; Dalal-NS
Source
Arch Biochem Biophys 1992 Jan; 292(1):323-327
NIOSHTIC No.
00205542
Abstract
The role of the superoxide radical (O2) in the cellular injury caused by exposure to chromium (7440473) (Cr) was investigated. Cr(VI) catalyzed the formation of the hydroxyl radical from superoxide by a Haber-Weiss type of cycle. Electron spin resonance and spin trapping techniques were used to monitor the formation of Cr(V) from the reduction of Cr(VI) by the superoxide radical and the subsequent generation of the hydroxyl radical by reaction of the Cr(V) species with hydrogen-peroxide. This work provided the first experimental evidence that Cr(VI) is capable of catalyzing a Haber- Weiss cycle to generate hydroxyl radicals; further, it offered a clue as to why molecular oxygen plays a fundamental role in the genotoxic reactions associated with exposure to Cr(VI) containing compounds. The usefulness of antioxidants as antagonists toward Cr(VI) related genotoxicity was implied.
Keywords
NIOSH-Publication; NIOSH-Cooperative-Agreement; Genotoxic-effects; Cell-damage; Cytotoxic-effects; Hexavalent-chromium-compounds; Biotransformation; Free-radicals; Carcinogens
CODEN
ABBIA4
CAS No.
7440-47-3
Publication Date
19920101
Document Type
Journal Article
Funding Amount
2937066
Funding Type
Cooperative Agreement
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U60-CCU-306149
Issue of Publication
1
ISSN
0003-9861
Priority Area
Pulmonary-system-disorders
Source Name
Archives of Biochemistry and Biophysics
State
DC
Performing Organization
Center to Protect Workers' Rights
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