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Potential role of platelet-activating factor in development of occupational lung disease: action as an activator or potentiator of pulmonary phagocytes.

Authors
Kang-JH; Dyke-K; Pailes-WH; Castranova-V
Source
NIOSH 1992; :1-30
Link
NIOSHTIC No.
00205496
Abstract
This study was designed to investigate whether platelet activating factor may be important in the inflammatory response of the lung to occupational dusts. The in-vitro exposure of alveolar macrophages to cotton dust at 4mg/kg, silica (14808607) at 10mg/ml, or coal dust at 10mg/kg caused a release of picomole levels of platelet activating factor with cotton dust being the most potent and coal dust the least. The platelet activating factor was released from alveolar macrophage about 10 minutes after in-vitro silica exposure. Platelet activating factor is a direct stimulant of polymorphonuclear leukocytes increasing chemiluminescence 2.3 times above control. The response of polymorphonuclear leukocytes to a second stimulant was also potentiated by platelet activating factor. Platelet activating factor was not a direct stimulant of alveolar macrophages in-vitro, having no stimulatory effect on chemiluminescence or superoxide anion release. Platelet activating factor did potentiate zymosan stimulated activation of chemiluminescence and superoxide release from alveolar macrophages by 117 and 30, respectively. The authors conclude that exposure of lung tissue to occupational dusts results in the release of platelet activating factor which may activate polymorphonuclear leukocytes and potentiate the responsiveness of alveolar macrophages to dust.
Keywords
NIOSH-Author; Respiratory-system-disorders; Lung-cells; Alveolar-cells; Immunology; Blood-analysis; Blood-cells; Dust-exposure; Dust-inhalation; Silica-dusts; Plant-dusts;
CAS No.
14808-60-7
Publication Date
19920101
Document Type
Other
Fiscal Year
1992
NTIS Accession No.
PB92-176775
NTIS Price
A03
NIOSH Division
DRDS
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders
Source Name
National Institute for Occupational Safety and Health
State
VA; WV
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