Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Influence of cigarette smoking on bronchoalveolar lavage cellularity in asbestos-induced lung disease.

Authors
Schwartz-DA; Galvin-JR; Merchant-RK; Dayton-CS; Burmeister-LF; Merchant-JA; Hunninghake-GW
Source
Am Rev Respir Dis 1992 Feb; 145(2)(Pt 1):400-405
NIOSHTIC No.
00205453
Abstract
The influence of cigarette smoking on bronchoalveolar lavage (BAL) fluid cellularity in asbestos (1332214) induced lung disease was investigated. The study group consisted of 73 white males with extensive occupational exposure to asbestos who were participating in an ongoing research program of interstitial and pleural occupational lung diseases. Twenty subjects, mean age 57.1 years, were disease free as evidenced by normal chest X-rays and normal pulmonary function tests. Twenty eight, mean age 63.3 years, had pleural fibrosis and 25, mean age 59.4 years, had asbestosis. The proportion of subjects who were current smokers in the disease free, fibrotic, and asbestotic groups was 10, 4, and 28%, respectively. These groups had a mean number of pack years smoking of 28.1, 20.5, and 42.2, respectively. BAL was performed. The lavage fluid was assayed for alveolar macrophages, lymphocytes, neutrophils, and eosinophils. Subjects with asbestosis had significantly elevated lavage fluid macrophage, neutrophil, and eosinophil counts. Subjects with pleural fibrosis had elevated BAL fluid lymphocyte counts. Current cigarette smokers had higher concentrations of lavage fluid macrophages, neutrophils, and eosinophils compared to never smokers. Pack years of smoking were significantly correlated with BAL fluid macrophage and neutrophil counts. Multivariate analysis applied to the data for the asbestotic patients showed that cigarette smoking accounted for 17 to 18% of the variance of the lavage fluid macrophage and eosinophil counts. Asbestosis accounted for 6 to 7% of the variance in BAL fluid macrophage, neutrophil, and eosinophil counts. The authors conclude that cigarette smoking strongly influences BAL fluid cellularity in patients with asbestosis but not those with asbestos associated pleural fibrosis. This suggests that cigarette smoking influences the pathogenesis of asbestosis.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Asbestos-workers; Lung-cells; Cigarette-smoking; Respiratory-system-disorders; Pulmonary-function; Humans; Occupational-exposure
Contact
David A. Schwartz, M.D., M.P.H., Pulmonary Disease Division, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242
CODEN
ARDSBL
CAS No.
1332-21-4
Publication Date
19920201
Document Type
Journal Article
Funding Amount
122514
Funding Type
Grant
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000093
Issue of Publication
2
ISSN
0003-0805
Priority Area
Pulmonary System Disorders
Source Name
American Review of Respiratory Disease
State
IA
Performing Organization
University of Iowa, Iowa City, Iowa
TOP