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The role of analytical techniques in the diagnosis of asbestos-associated disease.

Authors
Vallyathan-V; Green-FHY; Abraham-JL
Source
Crit Rev Clin Lab Sci 1985 Jan; 22(1):1-42
NIOSHTIC No.
00205416
Abstract
Diagnosis of asbestos (1332214) related disease using light microscopy (LM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray energy spectrometry (XES), selected area electron diffraction (SAED), and x-ray diffractometry (XRD) was reviewed. Discussion involved consideration of the following: asbestos minerals; asbestos uses; exposure sources (occupational, avocational, environmental); clinical and radiological features of asbestos associated diseases; disease pathology (pleural plaques, asbestosis, asbestos bodies and fibers, bronchogenic carcinoma, malignant mesothelioma, other cancers); the role of adjunct diagnostic techniques (tissue sampling, autopsy, lung biopsy, LM, extraction from tissues, SEM, XES, TEM, aspect ratio measurements, SAED, automated image analysis, XRD); the clinical and epidemiological significance of asbestos bodies and fibers; and medicolegal considerations. It was stated that LM has been useful in identifying asbestos fibers in environmental samples and in determining asbestos bodies in tissue sections and digests. Transmission electron microscopes with XES and SAED capabilities were able to provide information on morphology, crystal structure, and chemical composition of asbestos fibers; SEM was considered less useful since it cannot provide for electron diffraction. The authors conclude that microanalytical techniques are useful for confirming asbestos exposure diagnoses.
Keywords
NIOSH-Author; Asbestos-fibers; Diagnostic-techniques; Microscopic-analysis; Clinical-pathology; Clinical-diagnosis; Respiratory-system-disorders; Lung-fibrosis
CODEN
CRCLBH
CAS No.
1332-21-4
Publication Date
19850101
Document Type
Journal Article
Fiscal Year
1985
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1040-8363
NIOSH Division
DRDS
Priority Area
Respiratory-system-disorders
Source Name
Critical Reviews in Clinical Laboratory Sciences
State
WV; NY
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