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Health impact of mycotoxins in the home and workplace: an overview.

Authors
Sorenson-WG
Source
Biodeterioration Research 1989 Jan; 2:201-215
Link
NIOSHTIC No.
00205403
Abstract
The effects of pulmonary exposure to substances produced by fungi are discussed. Topics included: toxic volatile compounds of fungi, the occurrence of aflatoxin (1402682) in workplace aerosols, the occurrence of mycotoxins in fungal spores, the effects of mycotoxins in the lung, and the needs of future research. Fungi known to cause respiratory problems upon inhalation were reviewed along with the volatile agents they produce; many of the latter were associated with high 50% lethal doses but some had significant toxic effects. Data from studies on the effects of inhaled aflatoxin on humans demonstrated increased cancer rates in exposed individuals. Aflatoxin has been shown to be present in corn and peanut dust and highly toxic macrocyclic-trichothecenes have been found in the conidia of Stachybotrys-atra. Studies have shown that T-2 mycotoxin (21259201), patulin (149291), and penicillic-acid can inhibit protein and RNA synthesis and also phagocytosis in pulmonary alveolar macrophages. Exposure to 1000 parts per million aflatoxin has resulted in lung lesions in five of eight animals. The author concludes that inhalation exposure to fungi and fungal spores may represent an occupational health hazard for agricultural and other exposed workers.
Keywords
Toxic-effects; Occupational-exposure; Microorganisms; Respiratory-system-disorders; Hypersensitivity; Agricultural-workers; Immune-reaction
CAS No.
1402-68-2; 21259-20-1; 149-29-1
Publication Date
19890101
Document Type
Book or book chapter
Editors
O'Rear-CE; Llewellyn-GC
Fiscal Year
1989
NTIS Accession No.
NTIS Price
ISBN No.
0306432293
Priority Area
Respiratory-system-disorders
Source Name
Biodeterioration Research: General Biodeterioration, Degradation, Mycotoxins, Biotoxins, and Wood Decay
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