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Old and new reflections on dioxin.

Authors
Fingerhut-MA; Steenland-K; Sweeney-MH; Halperin-WE; Piacitelli-LA; Marlow-DA
Source
Epidemiology 1992 Jan; 3(1):69-72
NIOSHTIC No.
00205379
Abstract
The authors of a 1978 NIOSH study on the effects of dioxin discussed portrayal of their results as a mixture of previous and inconsistent findings. The study included all 5172 chemical workers in the United States who had work records verifying assignment to the production of 2,4,5-trichlorophenoxyacetic-acid (93765) or its precursor 2,4,5- trichlorophenol (95954), both contaminated with 2,3,7,8- tetrachlorodibenzo-p-dioxin (1746016) (TCDD). A standard epidemiologic method was used but findings differed from those of other reports. A 15% overall excess of all cancers was found; this excess reached 46% in a subcohort having exposures over 1 year and latencies over 20 years. This group also exhibited a 42% excess of respiratory cancer and a nine fold excess of soft tissue sarcoma. Contributions of other occupational carcinogens or smoking were not ruled out; but, the authors conclude that their results indicate that TCDD is a carcinogen.
Keywords
NIOSH-Author; Dioxins; Epidemiology; Chemical-factory-workers; Chlorinated-hydrocarbons; Cancer-rates; Occupational-exposure; Mortality-data
CODEN
EPIDEY
CAS No.
93-76-5; 95-95-4; 1746-01-6
Publication Date
19920101
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1044-3983
Source Name
Epidemiology
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