Does smoking status influence responsiveness to cotton bract extract?
Russomanno-J; Siegel-J; Witek-TJ Jr.; Rienzi-N; Zuskin-E; Buck-M; Schachter-EN
Cotton dust: proceedings of the Fifteenth Cotton Dust Research Conference, beltwide cotton conferences, January 11-12, 1991, San Antonio, Texas. Jacobs RR, Wakelyn PJ, Domelsmith LN, eds. Memphis TN: The National Cotton Council of America, 1991 Jan; :213-214
The effect of chronic cigarette smoking on responsiveness to cotton bract extract was investigated to determine if smokers are more susceptible to the effects of cotton dust than nonsmokers. On the first of two testing days, 20 healthy nonsmokers and 34 healthy smokers provided their medical histories and received physical examinations. Baseline spirometric measurements were taken and a methacholine challenge was performed with progressive doses of 0 to 200 milligrams. On the second day, baseline spirometry was again performed. A cotton bract extract (CBE) challenge (30 milligrams extract dissolved in distilled water then aerosolized) was performed. Lung function was assessed for 2 hours, after which time, a methacholine challenge study was conducted. More smokers responded to CBE than nonsmokers. Smokers also had more sensitive airway responses to methacholine. The authors conclude that, in smokers, CBE enhances airway reactivity.
NIOSH-Grant; Pulmonary-system-disorders; Cigarette-smoking; Cotton-dust; Dust-exposure; Inhalation-studies; Respiratory-hypersensitivity; Sensitivity-testing
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
Jacobs-RR; Wakelyn-PJ; Domelsmith-LN
Cotton dust: proceedings of the Fifteenth Cotton Dust Research Conference, beltwide cotton conferences, January 11-12, 1991, San Antonio, Texas
Mount Sinai School of Medicine, New York, New York