Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Does smoking status influence responsiveness to cotton bract extract?

Authors
Russomanno-J; Siegel-J; Witek-TJ Jr.; Rienzi-N; Zuskin-E; Buck-M; Schachter-EN
Source
Cotton dust: proceedings of the Fifteenth Cotton Dust Research Conference, beltwide cotton conferences, January 11-12, 1991, San Antonio, Texas. Jacobs RR, Wakelyn PJ, Domelsmith LN, eds. Memphis TN: The National Cotton Council of America, 1991 Jan; :213-214
Link
NIOSHTIC No.
00205091
Abstract
The effect of chronic cigarette smoking on responsiveness to cotton bract extract was investigated to determine if smokers are more susceptible to the effects of cotton dust than nonsmokers. On the first of two testing days, 20 healthy nonsmokers and 34 healthy smokers provided their medical histories and received physical examinations. Baseline spirometric measurements were taken and a methacholine challenge was performed with progressive doses of 0 to 200 milligrams. On the second day, baseline spirometry was again performed. A cotton bract extract (CBE) challenge (30 milligrams extract dissolved in distilled water then aerosolized) was performed. Lung function was assessed for 2 hours, after which time, a methacholine challenge study was conducted. More smokers responded to CBE than nonsmokers. Smokers also had more sensitive airway responses to methacholine. The authors conclude that, in smokers, CBE enhances airway reactivity.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Cigarette-smoking; Cotton-dust; Dust-exposure; Inhalation-studies; Respiratory-hypersensitivity; Sensitivity-testing
Contact
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
Publication Date
19910101
Document Type
Conference/Symposia Proceedings
Editors
Jacobs-RR; Wakelyn-PJ; Domelsmith-LN
Funding Amount
709316
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
NTIS Price
ISBN No.
9780961340889
Identifying No.
Grant-Number-R01-OH-02593
Priority Area
Pulmonary-system-disorders
Source Name
Cotton dust: proceedings of the Fifteenth Cotton Dust Research Conference, beltwide cotton conferences, January 11-12, 1991, San Antonio, Texas
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
TOP