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Effect of smoke inhalation on immediate changes in lung chemical mediators.

Authors
Witten-ML; Lantz-RC; Grad-R; Seidner-S; Hubbard-AK; Quan-SF; Lemen-RJ
Source
Res Commun Chem Pathol Pharmacol 1991 Dec; 74(3):259-271
Link
NIOSHTIC No.
00205082
Abstract
The immediate effects of smoke on alveolar function were assessed in rabbits. Anesthetized and ventilated New-Zealand-white-rabbits received 60 tidal volume breaths of diesel fuel/polycarbonate plastic smoke or sham smoke by injection into the endotracheal tube. After each breath of smoke, four to six ventilated breaths of air were given to each rabbit. The smoke was administered over a period of 8 to 9 minutes. Following exposure, the rabbits were killed and their lungs removed for lavage. Compared to the sham exposure group, the smoke exposure group exhibited a significant increase in leukotriene-B4 levels in lavage fluid with acute exposure. This group also exhibited decreased lung surfactant levels and decreased alveolar macrophage superoxide secretion after phorbol-myristate- acetate stimulation. The authors conclude that these alterations in chemical mediators may play a role in the lung injury caused by smoke inhalation.
Keywords
NIOSH-Author; Laboratory-animals; Smoke-inhalation; Respiratory-irritants; Lung-cells; Cell-function; Acute-exposure; Combustion-products; Inhalation-studies
CODEN
RCOCB8
Publication Date
19911201
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
0034-5164
Source Name
Research Communications in Chemical Pathology and Pharmacology
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