Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Reversible inhibition of intercellular communication among cardiac myocytes by halogenated hydrocarbons.

Authors
Toraason-M; Breitenstein-MJ; Wey-HE
Source
Fundam Appl Toxicol 1992 Jan; 18(1):59-65
NIOSHTIC No.
00204988
Abstract
The effect of ten aliphatic halogenated hydrocarbons was examined in addition to halothane (151677) on intercellular communication in cultured heart cells harvested from 2 to 4 day old Sprague-Dawley- rats. The other ten compounds tested included methylene-chloride (75092), 1,2-dichloroethane (107062), 1,1,2-trichloroethane (79005), chloroform (67663), trichloroethylene (79016), 1,1,1-trichloroethane (71556), carbon-tetrachloride (56235), tetrachloroethylene (127184), 1,1,1,2-tetrachloroethane (630206), and pentachloroethane (76017). Myocytes were suffused with increasing concentrations of halocarbon added as a 0.2% solution of dimethyl-sulfoxide to M199 containing 1.8 millimolar calcium and 5% serum. Single cells were microinjected with the fluorescent probe Lucifer-yellow and dye coupling to adjacent cells was monitored. The findings demonstrated the inhibition of the intercellular communication in cultured heart cells by each of the 11 halogenated hydrocarbons. The immediate and completely reversible action of these chemicals on gap junctional communication paralleled their ability to sensitize the myocardium to catecholamine induced arrhythmias. The inhibition of the intercellular communication appeared to be largely dependent on the ability of these compounds to partition in the cell membrane. These findings supported the theory that the physicochemical properties of the halocarbons are a major factor in their acute effect on the heart.
Keywords
NIOSH-Author; Cardiovascular-system-disorders; Laboratory-animals; Cytotoxic-effects; Cell-damage; Anesthetics; Pharmaceuticals; Chlorinated-hydrocarbons; Toxic-effects
CODEN
FAATDF
CAS No.
151-67-7; 75-09-2; 107-06-2; 79-00-5; 67-66-3; 79-01-6; 71-55-6; 56-23-5; 127-18-4; 630-20-6; 76-01-7
Publication Date
19920101
Document Type
Journal Article
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0272-0590
NIOSH Division
DBBS
Source Name
Fundamental and Applied Toxicology
State
OH
TOP