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Depression of contractility in cultured cardiac myocytes from neonatal rat by carbon tetrachloride and 1,1,1-trichloroethane.

Authors
Toraason-M; Krueger-JA; Breitenstein-MJ; Swearengin-TF
Source
Toxicol In Vitro 1990 Jul; 4(4-5):363-368
NIOSHTIC No.
00204901
Abstract
A study was conducted to evaluate the value of using isolated cells for investigating the cardiac effects of halogenated hydrocarbons. Hearts were harvested from Sprague-Dawley-rats. Carbon- tetrachloride (56235) (CCl4) and 1,1,1-trichloroethane (71556) (TCE) had a negative chronotropic effect on myocytes by prolonging the relaxation phase of beating. The duration of the contraction phase of beating, and the peak velocity of cell wall movement were not affected by these halocarbons. By 2.5 millimolar CCl4 or 5 millimolar TCE, beating was completely stopped. Beating activity resumed after these chemicals were washed out. The duration of contraction and relaxation phases of beating were significantly affected by increasing or decreasing the calcium concentration. The changes in calcium concentration did not alter the concentration dependent action of CCl4. The authors conclude that cultured heart cells are useful for assessing the cardiac depressant and sensitizing actions of halogenated hydrocarbons.
Keywords
NIOSH-Author; Chlorinated-hydrocarbons; Cell-cultures; Cell-function; Cell-damage; Cardiovascular-system-disorders; In-vitro-study; Cardiovascular-function; Halogenated-hydrocarbons
CODEN
TIVIEQ
CAS No.
56-23-5; 71-55-6
Publication Date
19900701
Document Type
Journal Article
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Issue of Publication
4-5
ISSN
0887-2333
NIOSH Division
DBBS
Source Name
Toxicology in Vitro
State
OH
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