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Intrapulmonary deposition and retention modeling of chrysotile asbestos fibers in rats.

Authors
Yu-CP; Asgharian-B; Pinkerton-KE
Source
J Aerosol Sci 1991 Jan; 22(6):757-763
NIOSHTIC No.
00204038
Abstract
A theoretical model was presented to simulate the deposition and clearance processes of chrysotile (12001295) asbestos fibers in an asymmetric lung in order to explain the observed nonuniformity. The lung burdens of fibers of different size ranges in each alveolar region of the rat lung were calculated for an exposure condition of 7 hours a day, 5 days a week for a 12 month period. Regions with fewer airway generations in their path had a higher value of fiber retention and a longer mean length. The smaller fiber accumulation in the region with high airway generation number was attributed to the greater loss by deposition along the airway path. The authors note that because deposition of fibers occurs mostly at airway bifurcations, an airway path ending at a higher airway generation number would have a larger deposition loss. Since long fibers have a higher deposition efficiency at the bifurcation than the short ones, a smaller fraction of long fibers will reach the alveolar space. The mean fiber length in a region of higher generation number will therefore be smaller.
Keywords
Tissue-distribution; Body-burden; Laboratory-animals; Lung-irritants; Alveolar-cells; Respiratory-system-disorders; In-vivo-study; Inhalation-studies; Asbestos-fibers; Airborne-fibers
CODEN
JALSB7
Publication Date
19910101
Document Type
Journal Article
Funding Amount
1055222
Funding Type
Cooperative Agreement
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U07-CCU-906162
Issue of Publication
6
ISSN
0021-8502
Source Name
Journal of Aerosol Science
State
CA
Performing Organization
University of California - Davis
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