Biochemical Principles of Cardiac Toxicology.
Principles of Cardiac Toxicology, S. I. Baskin, CRC Press, Boca Raton, Florida 1991:39-70
This chapter provided a brief overview of the general biochemistry of the heart, and a small number of extensively studied cardiac toxicants and toxins were discussed in an attempt to demonstrate the various ways xenobiotics can interfere with subcellular processes. Only specific cardiac effects were considered and not effects of substances on the vascular system. Energy metabolism and oxidative phosphorylation were discussed as they relate to carbohydrates, fatty acids, electron transport, oxidative damage, and ATPase. Also discussed were contractile proteins, calcium metabolism, adrenergic and cholinergic regulation, and gap junctions. Specific agents considered include adriamycin (25316409), allylamine (107119), halogenated hydrocarbons, digitalis (8031423), ethanol (64175), cocaine (50362), and animal toxins. Chemicals that have considerably different mechanisms of action often have a common attribute in that they ultimately interfere with the primary function of the heart to act as a pump. The initial insult can be manifested as altered calcium transport, blockade of electron transport, or phosphorylation of critical proteins. Such singular events can result in a cascade of effects that result in a seriously impaired myocardium. An agent can also have multiple effects on the heart and these can vary significantly depending on dose and duration of exposure. Extra cardiac effects such as modification of the vasculature or impairment of the sympathetic nervous system can indirectly impact the heart with serious consequences.
Cardiovascular-system-disorders; Alcohols; Drug-abuse; Medical-treatment; Drug-interaction; Toxic-effects; Cardiovascular-function; Heart-rate;
25316-40-9; 107-11-9; 8031-42-3; 64-17-5; 50-36-2;
Book or book chapter;
Principles of Cardiac Toxicology, S. I. Baskin, CRC Press, Boca Raton, Florida