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Mortality among workers exposed to ethylene oxide.

Authors
Wong-O; Steenland-K; Stayner-L
Source
N Engl J Med 1991 Oct; 325(17):1254
NIOSHTIC No.
00203496
Abstract
A letter to the editor was presented which reported a study of 1353 deaths through 1988 among workers exposed to ethylene-oxide (75218). The study revealed standardized mortality ratios of 0.86 (14 deaths) for leukemia and 1.02 (43 deaths) for hematopoietic cancer. There was no dose response relation according to the duration of exposure. The present results demonstrated that workers with similar levels of exposure to ethylene-oxide were not at increased risk for these two cancers and that the statement in the earlier study, that the results were inconclusive, was overly conservative. With regard to nonHodgkin's lymphoma, using a broader category, the study indicated a significant standardized mortality ratio of 2.47 for men, but no upward trend according to the duration of exposure. Specific jobs, responsible for the excess lymphoma were not identified. Analyses of nonHodgkin's lymphoma based on death certificates were limited by the inconsistent classification of the disease and by revisions in the International Classification of Disease (ICD) over time. A reply was also presented by the authors of the study which was referred to in this letter. They contend that they stand by their original results and point out that the study presented above, although based on the same data as their own, had 1 more year of follow up and that their data included both ICD 200 and ICD 202 revisions, although the results for each was reported separately.
Keywords
Epidemiology; Risk-analysis; Risk-factors; Cancer-rates; Carcinogenesis; Leukemogenesis; Laboratory-workers; Health-care-personnel; Statistical-analysis
CODEN
NEJMAG
CAS No.
75-21-8
Publication Date
19911024
Document Type
Other
Fiscal Year
1992
NTIS Accession No.
NTIS Price
Issue of Publication
17
ISSN
0028-4793
Source Name
New England Journal of Medicine
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