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Colchicine inhibits elevations in both alveolar-capillary membrane permeability and lavage surfactant after exposure of the rat to phosgene.

Authors
Ghio-AJ; Hatch-GE
Source
Division of Allergy, Critical Care, and Respiratory Medicine, Duke University School of Medicine, Durham, North Carolina 1991 Jan; :1-28
Link
NIOSHTIC No.
00203300
Abstract
Changes were measured in the permeability of the alveolar capillary membrane and lavage surfactant concentrations following phosgene (75445) exposure and the influence of colchicine on both. Male Sprague-Dawley-rats were treated with either colchicine at 1.0mg/kg or saline intraperitoneally 30 minutes prior to exposure to phosgene at 0.5 parts per million for 60 minutes and air. Lavage surfactant was quantified as the total phosphorus immediately and 1 day after exposure. The two sources of protein showed very different responses to phosgene. Permeability was elevated immediately but returned to normal values one day after inhalation. Values of total phospholipid in the lavage fluid showed no immediate differences between phosgene and air exposed rats. However, significant increases were observed 1 day after phosgene inhalation. Colchicine inhibited both the immediate rise in the permeability index and the elevation of total phospholipid 1 day after phosgene exposure.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Alveolar-cells; Lung-irritants; Laboratory-animals; Respiratory-system-disorders; Pulmonary-function; Alveolar-cells; Toxic-gases
Contact
Medicine University of Tennessee Room H-314, Coleman Bldg Memphis, TN 38163
CAS No.
75-44-5
Publication Date
19910101
Document Type
Final Grant Report
Funding Amount
574424
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
PB92-136332
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-02264
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Division of Allergy, Critical Care, and Respiratory Medicine, Duke University School of Medicine, Durham, North Carolina
State
NC; TN
Performing Organization
University of Tenn Center Health Scien, Memphis, Tennessee
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