Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Surface complexation of Fe(3+) by silica and silicate dusts increases in vitro oxidant generation but diminishes in vitro cytotoxicity.

Authors
Ghio-AJ; Crumbliss-AL
Source
Division of Allergy, Critical Care, and Respiratory Medicine, Duke University School of Medicine, Durham, North Carolina 1991 Jan; :1-22
Link
NIOSHTIC No.
00203279
Abstract
A study was conducted to test the hypothesis that in-vitro cytotoxicity by silica (7631869), crocidolite (12001284), kaolinite (1318747), and talc (14807966) correlates with surface complexed iron and subsequent oxidant generation. Silica, crocidolite, kaolinite and talc were either iron loaded in ferric-chloride or wetted with distilled water. The dusts were then examined for in- vitro oxidant generation and cytotoxicity using an assay for lipid peroxidation products of rat liver microsomes and hemolysis, respectively. While thiobarbituric-acid reactive products of microsomes were augmented by surface complexation of iron ions, hemolysis actually decreased. Oxidant generation by these mineral oxides increased over time while membranolysis was immediate and had no correlation with time. The authors conclude that in-vitro oxidant generation by silica and silicate dusts is not associated with hemolysis.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Oxidative-processes; Oxidation; Metal-oxides; Cytotoxic-effects; Mineral-dusts
Contact
Medicine University of Tennessee Room H-314, Coleman Bldg Memphis, TN 38163
CAS No.
7631-86-9; 12001-28-4; 1318-74-7; 14807-96-6
Publication Date
19910101
Document Type
Final Grant Report
Funding Amount
574424
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
PB92-136357
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-02264
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Division of Allergy, Critical Care, and Respiratory Medicine, Duke University School of Medicine, Durham, North Carolina
State
NC; TN
Performing Organization
University of Tenn Center Health Scien, Memphis, Tennessee
TOP