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The relation of polychlorinated biphenyls to birthweight and gestational age in the offspring of occupationally exposed mothers.

Authors
Taylor-PR; Stelma-J; Lawrence-CE
Source
NIOSH 1984 Sep; :1-29
Link
NIOSHTIC No.
00202721
Abstract
A study was made of the relation between occupational exposure of women to high homolog polychlorinated biphenyls (PCB) and birthweight and gestational age among the live offspring of these workers. In 1982 interviews were conducted with 200 women who had held jobs with direct PCB exposure. A comparison was made with 205 women who had never held such a job. When all births occurring to mothers following exposure to PCBs were considered, the unadjusted mean birthweight in the direct exposure group was 96 grams less than the comparison group. No differences in gestational age were seen between groups. The birthweight difference was reduced to 41 grams following adjustment for potential confounding factors. In a parallel analysis using a continuous exposure variable estimate generated from an independently derived serum PCB prediction model, no effect of PCBs was noted on birthweight or gestational age using either crude or adjusted analyses. The authors conclude that no evidence for a biologically meaningful effect of high homolog PCBs on gestational age or birthweight exists.
Keywords
NIOSH-Contract; Contract-210-81-5102; Reproductive-system-disorders; Reproductive-hazards; Embryotoxicity; Humans; Chlorinated-hydrocarbons; Transplacental-exposure; Occupational-exposure; Polychlorinated-biphenyls
CAS No.
11097-69-1
Publication Date
19840920
Document Type
Final Contract Report
Funding Type
Contract
Fiscal Year
1984
NTIS Accession No.
PB92-133297
NTIS Price
A03
Identifying No.
Contract-210-81-5102
Priority Area
Fertility and Pregnancy Abnormalities; Disease and Injury; Reproductive-system-disorders;
Source Name
Statistical and Computer Science Laboratory, Wadsworth Center for Labs and Research, New York State Department of Health, NIOSH Contract No. 210-81-5102, 29 pages, 15 references
State
NY
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