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Immune responsiveness in chlorine exposed rats.

Authors
O'Neil-CE
Source
Section of Allergy and Clinical Immunology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 1991 May; :1-21
Link
NIOSHTIC No.
00201858
Abstract
A mouse model was developed to test the hypothesis that acute exposure to high levels of chlorine (7782505) gas can increase sensitivity to inhaled antigen. This initial survey was designed to assess whether there was an increase in sensitivity to antigen and whether the effect was transient or of extended duration. BALB/c- mice were exposed to 200 or 150 parts per million (ppm) chlorine for 1 hour. The animals were then exposed to 1% aerosolized bovine serum albumin (BSA) immediately or 1, 3, 7, and 30 days after exposure. Exposures were for 30 minutes a day for 5 consecutive days. The findings indicated that in mice, acute exposure to 200ppm followed immediately by exposure to BSA resulted in increased levels of antigen specific immunoglobulin-G when compared to control values. Mice exposed acutely to lower levels of chlorine or to antigen at more distant time points following the irritant exposure did not demonstrate any increased antibody levels.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Immune-reaction; Toxic-gases; Antibody-response; Laboratory-animals; Inhalation-studies; Toxic-effects
Contact
Medicine Tulane Medical Center 1700 Perdido Street New Orleans, LA 70112
CAS No.
7782-50-5
Publication Date
19910520
Document Type
Final Grant Report
Funding Amount
45000
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
PB92-124478
NTIS Price
A03
Identifying No.
Grant-Number-R03-OH-02425
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Section of Allergy and Clinical Immunology, Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana
State
LA
Performing Organization
Tulane University of Louisiana, New Orleans, Louisiana
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