Ninety day toxicity study of chloroacetic acids in rats.
Bhat-HK; Kanz-MF; Campbell-GA; Ansari-GA
Fundam Appl Toxicol 1991 Aug; 17(2):240-253
A study was made of the toxicities of the chloroacetic acids based on an approximate intake of one quarter of the median lethal dose per day. Male Sprague-Dawley-rats were administered 80.5 millimolar (mM) dichloroacetic-acid (79436) (DCA), 45.8mM trichloroacetic-acid (76039) (TCA) or 1.9mM monochloroacetic-acid (79118) (MCA) in their drinking water for 90 days. Light microscopic examination of the major organs revealed variable degrees of alterations in the lung and liver of all three treated groups. DCA produced the most severe alterations in body weight and organ weights; changes were less severe with TCA, and MCA caused only minor changes. In the liver, morphological changes were predominantly localized to the portal triads, which were mildly to moderately enlarged with random bile duct proliferation, extension of portal veins, fibrosis, edema, and occasional foci of inflammation. In the lungs, minimal alterations were noted as foci of perivascular inflammation on small pulmonary veins. Morphological changes in the testes and brain were noted only in the DCA treated group. Testes were atrophic with few spermatocytes and no mature spermatozoa. Focal vacuolation and gliosis were present in the forebrain and brainstem. The results of these studies indicated that, relative to their respective median lethal values, DCA is more toxic than TCA, and MCA is the least toxic.
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Laboratory-animals; Respiratory-system-disorders; Chlorinated-hydrocarbons; Acetic-acids; Toxic-effects; Drinking-water
Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
79-43-6; 76-03-9; 79-11-8
Fundamental and Applied Toxicology
University of Texas Medical Branch, Galveston, Texas