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Ninety day toxicity study of chloroacetic acids in rats.

Authors
Bhat-HK; Kanz-MF; Campbell-GA; Ansari-GA
Source
Fundam Appl Toxicol 1991 Aug; 17(2):240-253
NIOSHTIC No.
00201694
Abstract
A study was made of the toxicities of the chloroacetic acids based on an approximate intake of one quarter of the median lethal dose per day. Male Sprague-Dawley-rats were administered 80.5 millimolar (mM) dichloroacetic-acid (79436) (DCA), 45.8mM trichloroacetic-acid (76039) (TCA) or 1.9mM monochloroacetic-acid (79118) (MCA) in their drinking water for 90 days. Light microscopic examination of the major organs revealed variable degrees of alterations in the lung and liver of all three treated groups. DCA produced the most severe alterations in body weight and organ weights; changes were less severe with TCA, and MCA caused only minor changes. In the liver, morphological changes were predominantly localized to the portal triads, which were mildly to moderately enlarged with random bile duct proliferation, extension of portal veins, fibrosis, edema, and occasional foci of inflammation. In the lungs, minimal alterations were noted as foci of perivascular inflammation on small pulmonary veins. Morphological changes in the testes and brain were noted only in the DCA treated group. Testes were atrophic with few spermatocytes and no mature spermatozoa. Focal vacuolation and gliosis were present in the forebrain and brainstem. The results of these studies indicated that, relative to their respective median lethal values, DCA is more toxic than TCA, and MCA is the least toxic.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Laboratory-animals; Respiratory-system-disorders; Chlorinated-hydrocarbons; Acetic-acids; Toxic-effects; Drinking-water
Contact
Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
CODEN
FAATDF
CAS No.
79-43-6; 76-03-9; 79-11-8
Publication Date
19910801
Document Type
Journal Article
Funding Amount
721590
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02149
Issue of Publication
2
ISSN
0272-0590
Priority Area
Pulmonary-system-disorders; Respiratory-system-disorders
Source Name
Fundamental and Applied Toxicology
State
TX
Performing Organization
University of Texas Medical Branch, Galveston, Texas
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