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Toxicological effect of vanadium on the macrophage response to Listeria challenge.

Authors
Wei-CI
Source
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 1991 Jun; :1-10
Link
NIOSHTIC No.
00201449
Abstract
The decreased resistance of mice to Listeria-monocytogenes following vanadium (7440622) treatment was investigated. Female B6C3F1-mice were injected intraperitoneally with ammonium-metavanadate (7803556), every 3 days for 6 weeks, and then injected with 2x10(4) L-monocytogenes. Vanadium exposure interfered with both the uptake and ultimate intraphagolysosomal killing of Listeria. Vanadium treatment resulted in altered patterns of clearance of the bacteria from the peritoneal cavity, liver, and spleen. Peritoneal macrophages from vanadium treated mice were coincubated with Listeria. The total in-vitro phagocytic uptake of Listeria by peritoneal macrophages (PEM) was consistently decreased as a function of infection period. Intracellular killing of Listeria was decreased although PEM from vanadate treated mice were more bacteriostatic than bactericidal. Vanadium exposure resulted in a dose trend depression in three cytoplasmic enzymes crucial to PEM function. Vanadium treatment resulted in a similar decrease in the production of superoxide anion, and an increase in levels of oxidized glutathione. The total glutathione pool was not affected. The authors conclude that the decreased bactericidal activity in PEM of vanadate treated mice was not due to direct inhibition of either activity or synthesis of beta-glucuronidase, N-acetyl-beta-D- glucosaminidase, or lysozyme.
Keywords
NIOSH-Grant; Grants-other; Enzyme-activity; Laboratory-animals; Vanadium-compounds; Alveolar-cells; Bacterial-infections; Toxic-effects
Contact
Food Science & Human Nutrition University of Florida Gainesville, FL 32611 Gainesville, FL 32611
CAS No.
7440-62-2; 7803-55-6
Publication Date
19910605
Document Type
Final Grant Report
Funding Amount
43500
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
PB92-115682
NTIS Price
A02
Identifying No.
Grant-Number-R03-OH-02583
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida
State
FL
Performing Organization
University of Florida, Gainesville, Florida
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