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Epithelial Surface Proteins: Markers of Cancer Risk.

Authors
Merrill-WW; Cullen-MR; Carter-D; Horwitz-R; Matthay-RA; Gee-JB
Source
Yale University School of Medicine, New Haven, Connecticut 1991 Feb:51 pages
Link
NIOSHTIC No.
00201448
Abstract
The relationship between proteins synthesized by airway mucosal cells and the presence of metaplasia detectable in biopsies of the bronchial mucosa was determined. Bronchoalveolar lavage and airway biopsies were performed on 50 subjects who had a history of occupational exposure to asbestos (1332214). All but eight of the subjects were current or former smokers. Metaplasia seen in mucosal biopsies and change in diffusion capacity for carbon-monoxide (CO) were used as surrogates for cancer risk and pulmonary fibrosis respectively. A third of the subjects showed keratinizing metaplasia, however, keratinizing metaplasia could not be related to levels of free secretory component or the keratins in lavage fluid. Cigarette smoking and the number of acute inflammatory cells were related to keratinizing metaplasia; nonsmokers had the lowest frequency of metaplasia, and current smokers had the highest frequency. When diffusion capacity was used as a surrogate for functional deterioration, acute inflammatory cells were statistically related to the rate of lung functional loss over time. Other occupational and demographic factors were not found to be significantly associated with metaplasia or functional deterioration.
Keywords
NIOSH-Grant; Respiratory-system-disorders; Occupational-exposure; Asbestos-fibers; Asbestos-workers; Humans; Cigarette-smoking; Risk-analysis; Lung-function; Lung-cancer;
Contact
Internal Medicine Yale University School of Med 109-Lci, P O Box 3333 New Haven, CT 06520
CAS No.
1332-21-4;
Publication Date
19910207
Document Type
Final Grant Report;
Funding Amount
410648.00
Funding Type
Grant;
Fiscal Year
1991
NTIS Accession No.
PB92-115674
NTIS Price
A05
Identifying No.
Grant-Number-R01-OH-02114
NIOSH Division
OEP
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Source Name
Yale University School of Medicine, New Haven, Connecticut
State
CT;
Performing Organization
Yale University, New Haven, Connecticut
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