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Immunological and respiratory changes in soy bean workers.

Authors
Zuskin-E; Kanceljak-B; Schachter-EN; Witek-TJ Jr.; Marom-Z; Goswami-S; Maayani-S
Source
Int Arch Occup Environ Health 1991 May; 63(1):15-20
NIOSHTIC No.
00200980
Abstract
The relationship between immunological findings, respiratory symptoms and ventilatory capacity was examined in 19 male soybean mill workers and a comparison group of 31 transportation workers not exposed to soybean dust. Positive skin reactions were demonstrated by all workers in response to histamine and to soybean dust. Eighteen were positive for the antigen prepared from soybean after separation from oil. Three were positive for the soy lecithin antigen only and only one responded to the soy oil antigen. In three of 19 workers, increased serum levels of specific immunoglobulin-E (IgE) were found. Positive reactions to household dust were obtained from 13. An increased serum level of specific IgE was found in one of the comparison workers. Higher prevalences of almost all chronic respiratory symptoms were found in soy workers than in controls. A high prevalence of acute symptoms associated during the work shift in soybean workers was noted. Ventilatory capacity studies made over work shifts in the 19 workers showed a significant across shift reduction. Environmental measurements indicated a high dust concentration with mean total dust readings of 29.5mg/m3 and a respirable fraction of 3.5mg/m3. A dose related contractile effect of the water soluble soybean shell extract was noted on isolated smooth muscle of the guinea-pig trachea. The large number of comparison workers who also demonstrated a positive skin test to soybean dust suggests that many of the observed reactions are irritative and not antibody related.
Keywords
NIOSH-Publication; NIOSH-Grant; Respiratory-system-disorders; Dust-exposure; Plant-substances; Plant-dusts; Allergic-reactions; Bronchial-asthma; Immune-reaction; Humans; Dust-inhalation; Skin-exposure; Food-processing-industry
Contact
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
CODEN
IAEHDW
Publication Date
19910501
Document Type
Journal Article
Funding Amount
709316
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02593
Issue of Publication
1
Priority Area
Pulmonary-system-disorders
Source Name
International Archives of Occupational and Environmental Health
State
NY
Performing Organization
Mount Sinai School of Medicine, New York, New York
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