Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Development of a classification strategy of exposure for industry-based studies.

Authors
Kauppinen-TP
Source
Appl Occup Environ Hyg 1991 Jun; 6(6):482-487
NIOSHTIC No.
00200882
Abstract
A review was presented of exposure related classification variables in epidemiological studies of occupational hazards, and suggested criteria for selection of exposure indicators to obtain maximal information were outlined. The basis of classification criteria included description of evidence, internal validity, external validity and comparability of results with other available evidence. Exposure classification required selection of a study population to achieve clear delineation between exposure and nonexposure, availability of good quality data and other reliable information, no unresolvable confounding factors and a large enough population for powerful analysis. Important to causal associations were reasonable time relationship of exposure to disease, dose response relationship and internal consistency. Study hypotheses required accurate formulation with reference to specific agents and their characteristics and possible modifiers or confounders. Often, the primary restricting factor for exposure assessment was availability and quality of data on work histories and exposure levels. Exposure stratification variables could include proxy of qualitative exposure; qualitative exposure to an agent; ordinal, semiquantitative or quantitative exposure; time relationship of exposure or its proxy; and adjusted and joint exposure indicators. Advantages and disadvantages were discussed along with possibilities for exposure misclassification. Model calculations were used to demonstrate mutual relationships of exposure indicators. Exposure misclassification or other mechanisms could cause serious biasing of risk and exposure response relationships when proxies of exposure or target dose were used. Good prediction of outcome was likely for indicators adjusted for main confounders and modifiers and those addressing exposure pattern or mode, when the effect of such factors was strong.
Keywords
NIOSH-Publication; NIOSH-Contract; Contract-91-38661; Humans; Occupational-exposure; Epidemiology; Exposure-levels; Analytical-models; Occupational-hazards; Industrial-hygiene; Occupational-health; Risk-analysis
CODEN
AOEHE9
Publication Date
19910601
Document Type
Journal Article
Funding Type
Contract
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
Contract-91-38661
Issue of Publication
6
ISSN
1047-322X
Source Name
Applied Occupational and Environmental Hygiene
TOP