Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Issues in performing retrospective exposure assessment.

Authors
Stewart-PA; Herrick-RF
Source
Appl Occup Environ Hyg 1991 Jun; 6(6):421-427
NIOSHTIC No.
00200874
Abstract
A discussion was presented of limitations of traditional retrospective exposure measures and benefits of quantitative exposure assessments. Use of a subject's employment within an industry or job as a surrogate for exposure was compared with use of specific exposures. Analysis of relative risks of laryngeal cancer based on employment in a specific industry yielded lower risks than those produced by analysis by potential exposures to specific chemicals. Only the latter produced statistically significant associations. Analysis by job titles gave similar estimates as those from exposure analyses, but larger confidence intervals were obtained in the former. Job title analyses did not directly relate to specific types of exposures. Dose response relationships could be studied using duration of employment or exposure as surrogates for actual exposure data only when certain conditions were met. Analysis of exposure monitoring data obtained from 1930 to 1975 in a chrysotile (12001295) asbestos facility demonstrated that exposure levels varied between time periods and among departments. Thus, inappropriate grouping by duration of employment or exposure could produce serious misclassification of exposures. A study of formaldehyde (50000) exposure data revealed a poor association of employment duration with estimated exposures. Analysis of data from 25 studies indicated better exposure response relationships for cumulative exposure and exposure intensity compared with exposure duration. A semiquantitative approach based on relative exposure categories arbitrarily assigned weights to each category, which could cause misclassifications. Development of quantitative estimates and use of these to classify subjects by exposure categories could reduce potential exposure misclassifications. The authors conclude that use of the most quantitative procedure possible for exposure estimates reflective of dose will increase the power of epidemiologic studies of exposure response relationships.
Keywords
NIOSH-Publication; NIOSH-Author; NIOSH-Contract; Contract-91-38661; Humans; Occupational-health; Occupational-exposure; Exposure-levels; Epidemiology; Quantitative-analysis; Risk-analysis; Statistical-analysis; Industrial-exposures
CODEN
AOEHE9
CAS No.
12001-29-5; 50-00-0
Publication Date
19910601
Document Type
Journal Article
Funding Type
Contract
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
Contract-91-38661
Issue of Publication
6
ISSN
1047-322X
Source Name
Applied Occupational and Environmental Hygiene
TOP