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In vitro glial responses to halothane metabolite, TFA.

Authors
Tseng-MT
Source
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 1991 May; :1-8
Link
NIOSHTIC No.
00200826
Abstract
Exponentially grown C6-murine glioma cells were used to study the effects of the halothane (151677) metabolite trifluoroacetic-acid (76051) (TFA) on cell growth; DNA, glycoprotein, and dolichol linked oligosaccharide synthesis; and ribonucleotide triphosphate concentrations. A slight concentration dependent enhancement of cell growth and tritium labeled thymidine incorporation followed 1 day of treatment with TFA. The leucine incorporation was elevated in a time and dose dependent manner following exposure for 1 or 5 days to TFA. The authors suggest that TFA stimulated cell growth and enhanced protein synthesis. A dose dependent effect was also noted on mannose incorporation into glycoprotein and dolichol linked oligosaccharides. TFA accelerated lectin induced cell aggregation. TFA apparently alters plasmalemmal glycoprotein synthesis. According to the authors, these findings should assist in forming a basis for furthering the understanding of the mechanisms underlying halothane associated neurotoxicity.
Keywords
NIOSH-Grant; Neurotoxic-effects; Protein-chemistry; Nervous-system-disorders; Neurotoxicology; Anesthetics
Contact
Anatomy University of Louisville Anatomy and Neurobiology Louisville, KY 40292
CAS No.
151-67-7; 76-05-1
Publication Date
19910501
Document Type
Final Grant Report
Funding Amount
43589
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
PB92-107952
NTIS Price
A02
Identifying No.
Grant-Number-R03-OH-02578
NIOSH Division
OEP
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky
State
KY
Performing Organization
University of Louisville, Louisville, Kentucky
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