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Halogenated Hydrocarbon Toxicity in Proximal Tubules.

Authors
Hjelle-JT; Miller-MA
Source
College of Medicine at Peoria, University of Illinois, Peoria, Illinois 1991 May:11 pages
Link
NIOSHTIC No.
00200824
Abstract
A study was conducted to examine the validity of the isolated rabbit tubule model as a tool in the study of nephrotoxicants and to determine the validity of the rabbit tubule model as a predictor of nephrotoxicity in humans. Kidney proximal tubules were isolated from control and phenobarbital induced rabbits by nonenzymatic sieving techniques and then studied in-vitro. Proximal tubules obtained in bulk by nonenzymatic procedures were resistant to cell damage by levels of chloroform (67663) and carbon-tetrachloride (56235) likely to be encountered in the work place. Drug treatment of the rabbits followed by tubule isolation and exposure to these solvents in-vitro did not enhance cell damage. Tubule cells propagated in-vitro were more susceptible to cell damage caused by these organic solvents.
Keywords
NIOSH-Grant; Grants-other; Laboratory-animals; Renal-toxicity; Chlorinated-hydrocarbons; Kidney-damage; In-vitro-studies;
Contact
Basic Sciences University of Illinois One Illini Drive, Box 1659 Peoria, IL 61656
CAS No.
67-66-3; 56-23-5;
Publication Date
19910514
Document Type
Final Grant Report;
Funding Amount
279085.00
Funding Type
Grant;
Fiscal Year
1991
NTIS Accession No.
PB92-109271
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-02417
NIOSH Division
OEP
Priority Area
Other Occupational Concerns; Grants-other;
Source Name
College of Medicine at Peoria, University of Illinois, Peoria, Illinois
State
IL;
Performing Organization
College of Medicine at Peoria, Peoria, Illinois
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