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NEG and NIOSH basis for an occupational health standard: propylene glycol ethers and their acetates.

Authors
Johansson-G
Source
NIOSH 1991 Jan; :1-53
NIOSHTIC No.
00199715
Abstract
The propylene glycol ethers and their acetates were reviewed as background for discussion of occupational exposure limits. The most commonly used propylene glycols in industry were 1-methoxy-2- propanol (107982), 2-methoxy-1-propanol (1320678), 1-methoxy-2- propyl-acetate (108656), 2-methoxy-1-propyl-acetate (70657704) and dipropylene-glycol-monomethyl-ether (34590948). The report included information concerning ambient air levels at the workplace, analytical methods for air monitoring, toxicokinetics (uptake, probably routes of human exposure, distribution, biotransformation, elimination, and biological exposure indicators), general toxicology (toxic mechanisms and in-vitro studies, factors influencing toxicity, and general effects), organ effects (skin and mucous membranes, respiratory system, liver, kidneys, gastrointestinal tract, circulatory system, hematological system, central nervous system, and peripheral nervous system), immunotoxicity and allergy, mutagenicity, genotoxicity, carcinogenicity, reproductive toxicity, dose effect and dose response relationships (short term exposure, and long term exposure), and research needs.
Keywords
Solvents; Toxic-effects; Solvent-vapors; Organic-solvents; Air-quality-monitoring; Occupational-exposure; Analytical-methods; Biological-effects; Gene-mutation; Genotoxic-effects; Health-standards
CAS No.
107-98-2; 1320-67-8; 108-65-6; 70657-70-4; 34590-94-8
Publication Date
19910101
Document Type
Numbered Publication; Criteria Document
Fiscal Year
1991
NTIS Accession No.
PB91-220749
NTIS Price
A05
Identifying No.
(NIOSH) 91-103
NIOSH Division
DSDTT
Source Name
National Institute for Occupational Safety and Health
State
OH
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