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Limitations in the use of particle size-selective sampling criteria in occupational epidemiology.

Authors
Hewett-P
Source
Appl Occup Environ Hyg 1991 Apr; 6(4):290-300
NIOSHTIC No.
00199604
Abstract
An examination was made to determine the potential differences between deposited particulate (dose) and measured particulate (exposure) using devices that sample according to the American Conference of Governmental Industrial Hygienists and (ACGIH) and International Standards Organization (ISO) criteria and to assess the effect of these differences on epidemiological dose response studies. Results indicated that the amount of bias varied with both geometric mean and geometric standard deviation. Therefore there would be a different exposure/dose relationship and exposure/response relationship for each particle size distribution. This would result in additional variability in exposure/response analyses unless all members of a given cohort were exposed to the same particle distribution. The author concludes that exposure measurements based on either the ACGIH or ISO collection efficiency curve may not be suitable for occupational epidemiology. If groups within a cohort are exposed to substantially different particle size distributions, total mass measurements and particle size distribution data should be collected. The mass distribution, coupled with lung deposition curves, can then be used to calculate an exposure that more accurately estimates dose or deposited particulate. The resulting exposure data will have less variability and should improve the probability of observing a significant exposure/response relationship.
Keywords
NIOSH-Author; Epidemiology; Airborne-particles; Tissue-distribution; Body-burden; Inhalants; Sampling-methods; Aerosols; Air-sampling; Air-quality-monitoring
CODEN
AOEHE9
Publication Date
19910401
Document Type
Journal Article
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
1047-322X
Source Name
Applied Occupational and Environmental Hygiene
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