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New developments in asbestos-induced pleural disease.

Authors
Schwartz-DA
Source
Chest 1991 Jan; 99(1):191-198
NIOSHTIC No.
00199385
Abstract
Asbestos (1332214) induced pleural disease was reviewed and discussed. Topics included prevalence, pathogenesis, roentgenographic changes, pulmonary function, and determinants of restrictive lung function in pleural fibrosis. Studies have indicated that pleural fibrosis is the most common of the asbestos induced abnormalities. It has been underdiagnosed and has been associated with restrictive lung function which appeared to be independent of its association with parenchymal fibrosis. Little work has been done to investigate the accuracy of the current criteria for pleural fibrosis established by the ILO, the anatomic and functional validity of these criteria, and the determinants of restrictive lung function in persons with asbestos induced pleural fibrosis. Results from these studies will have clear implications for clinical assessment and management of workers with asbestos induced pleural disease. Several pieces of evidence suggested that parenchymal inflammation and/or fibrosis are the principle determinants of restrictive lung function in persons with asbestos induced pleural fibrosis who have normal appearing parenchyma on the chest radiogram. Findings suggested that although parenchymal inflammation and fibrosis contribute to the loss of lung function in persons with asbestos induced pleural fibrosis, other mechanisms may contribute to the impaired lung function.
Keywords
NIOSH-Grant; Mineral-dusts; Occupational-exposure; Asbestos-workers; Respiratory-system-disorders; Lung-irritants; Lung-function; Airway-obstruction
Contact
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
CODEN
CHETBF
CAS No.
1332-21-4
Publication Date
19910101
Document Type
Journal Article
Funding Amount
122514
Funding Type
Grant
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000093
Issue of Publication
1
ISSN
0012-3692
Priority Area
Pulmonary System Disorders
Source Name
Chest
State
IA
Performing Organization
University of Iowa, Iowa City, Iowa
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