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Should dust samplers mimic human lung deposition?

Authors
Soderholm-SC; McCawley-MA
Source
Appl Occup Environ Hyg 1990 Dec; 5(12):829-830
NIOSHTIC No.
00198901
Abstract
The early history of airborne dust measurements was briefly reviewed and the cases both for and against designing dust samplers to mimic the actual deposition of the particles in the human lung were advanced. In arguments for the measure, it was stated that the Air Sampling Procedures (ASP) Committee of the ACGIH recognizes that in epidemiological studies it is necessary to estimate the delivered dose as closely as possible which is best accomplished by sampling with a cascade impactor and determining the composition of the collected dust as a function of particle size. For routine monitoring to determine whether particle concentrations are below established health based limits, the ASP Committee suggested that atmospheres be characterized using IPM, TPM, and RPM samplers (inhalable, thoracic, or respirable particular matter). One advantage of measuring size distributions with high or low resolution devices instead of developing mean dose samples is that all dust sampling for epidemiological studies and for routine hazard evaluations would require only two types of hardware and expertise in their use. In arguing against the measure, various assumptions of those encouraging the measure were critically reviewed. These included the assumption that dose is a function of the size fraction deposited, that a representative route of entry can be selected for the aerosol, that deposition can be represented for the population by some average curve, and that measured exposure should be in constant proportion to dose. It is suggested that future research develop particle size selective sampling criteria to determine the size distribution of the aerosol and apply both deposition and penetration criteria to determine if the correlation between measured exposure and response can be enhanced.
Keywords
NIOSH-Author; Airborne-dusts; Dust-exposure; Aerosol-sampling; Tissue-distribution; Body-burden; Respiratory-system-disorders; Lung-function; Pulmonary-function; Dust-samplers; Particulate-sampling-methods
CODEN
AOEHE9
Publication Date
19901201
Document Type
Journal Article
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Issue of Publication
12
ISSN
1047-322X
Priority Area
Respiratory-system-disorders
Source Name
Applied Occupational and Environmental Hygiene
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